Symposium lectures on-line

Most of the lectures of the Symposium were published on-line. You can find the video presentations at the top of each lecture abstract. We hope to complete the whole on-line program in the near feature.

Pictures of Semmelweis Symposium 2008

You can find the pictures of all the three days of Semmelweis Symposium 2008 here.

Lecture of Prof. Sándor Kovács

You can find the whole video-presentation of Prof. Sándor Kovács at "Lectures" on the following page.

Summary

More than 500 participants from 20 countries attended Semmelweis Symposium 2008. You can find a detailed summary of the event here. A summary of press echo in the Hungarian media you can find here.

Poster abstracts

You can find the poster abstracts of Semmelweis Symposium 2008 here.

Scientific Program - printable version

You can download the printable version of the Scientific Program here.

Cardiovascular pharmacogenomics course

According to the program of Semmelweis Symposium, Peter Pokreisz (Katholieke Universiteit Leuven, Belgium) will give a lecture (in Hungarian) on cGMP regulatory mechanisms in cardiology at 18:00 Wednesday, 26 November.

Abstract submission period extended

The deadline for abstract submission was extended until 18 November 2008. More detailes on the Abstract submission form.

On-line registration

Participation in the program of Semmelweis Symposium 2008 is free.
However, completion the on-line registration form is required to attend the Symposium.

Abstract submission for poster presentation

Abstracts for poster presentation are welcome to the Semmelweis Symposium. Deadline for abstract submission  is 15 November. More detailes on the Abstract Submission Form.

PhD course registration

Semmelweis Symposium 2008 was accredited by the School of Doctoral Studies of Semmelweis University. Students attending all the three days of the Symposium will get 2 PhD credits.

OFTEX registration

Semmelweis Symposium 2008 was registred to the OFTEX system. Colleagues attending all the three days of the Symposium will get 20 OFTEX credits. For detailed information look for SE-TK/2008-07/00383 at www.oftex.hu .

Final program

The final program of the Symposium has been completed. For detailes visit to the Scientific Program pages.

Current trends in Cardiology

This year cardiology is in the focus of Semmelweis Symposium. The members of the Heart Center take the opportunity to kindly invite you to this event.

Significance of stents - implanted metal tubes or meshes to prevent or counteract a disease-induced localized flow constriction - is rather high in cardiology. Development of tissue-friendly materials has mainly resolved the immunological problems rised by the tiny implants, however, their biological adaptation to the body of recipient is far from the  complete one (i.e. induction of inflammations, occlusions). In the present work our objectives were: (i) to develop a new, silicone-based subtance for coverage of stents; (ii) to evaluate endothelial cell adhesion on candidate silicone surfaces; (iii) to evaluate migratory activity of adherent cells; (iv) to test effect of precoating of silicons with fibronectin, the significant component of ECM as well as (v) effect of application of chemotactic targeting molecule, a fragment of GnRH molecule on the process. Eight derivatives of silicone were tested: silicone  (S1); silicone+aminoaethyl-aminopropyl-trimethoxy-silane (ATS) (S2, S3, S4); silicone+glycerol (G1, G2) as well as combinations of the two components (S1-G1; S1-G2).  Silicon network was developed under gas-phase catalysis; the samples were washed with 10% ethanol.  Investigated model cell-line was HMEC-1 human microvasular endothel (density 105cell/ml).  Adhesion experiments were carried out in 24-well tissueculture plates; the incubation time was 24 hrs. Cell adhesion to silicone free surfaces was evaluated as well as adhesion to wells where half of the bottoms were covered by the silicone derivative (self-control experiments). Effect of human fibronectin precoating was evaluated in 2ug/cm2, GnRH was applied on 10-6M.  Migratory activity of cells was evaluated in cloning-cylinder assays, incubation time was 48hr. For image analysis of silicone surfaces (adhesion, migration assays) Image J program was used. Our results show that: (i) S1 and S2 derivatives – whithout any pretreatment - could induce a moderate adhesion, while the others were cell free (surfaces coated with G1 and G2 were destroyed by the medium). (ii) Precoating of surfaces with fibronectin  could significantly increase the adhesion of cells on surfaces S1, S2, S3, S4. (iii) The chemotactic targeting molecule GnRH could elicit a weak positive effect on the S1 fibronectin coated surfaces as well as (iv) only the fibronectin coated S1, S2, S3 and S4 surfaces could promote not only cell adhesion but migration, too. Conclusions: On the basis of our present results silicone and  its compositions with aminopropyl-trimethoxy-silane proved to be good candidate substances, however, providing of physiological environment (fibronectin and GnRH) are still essential to achieve the optimal coverage of stents.