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Symposium lectures on-line
20 February, 2009
Most of the lectures of the Symposium were published on-line. You can find the video presentations at the top of each lecture abstract. We hope to complete the whole on-line program in the near feature.
Pictures of Semmelweis Symposium 2008
1 January, 2009
You can find the pictures of all the three days of Semmelweis Symposium 2008 here. Lecture of Prof. Sándor Kovács
31 December, 2008
You can find the whole video-presentation of Prof. Sándor Kovács at " Lectures" on the following page.
Summary
30 November, 2008
More than 500 participants from 20 countries attended Semmelweis Symposium 2008. You can find a detailed summary of the event here. A summary of press echo in the Hungarian media you can find here.
Poster abstracts
27 November, 2008
You can find the poster abstracts of Semmelweis Symposium 2008 here.
Scientific Program - printable version
23 November, 2008
You can download the printable version of the Scientific Program here.
Cardiovascular pharmacogenomics course
22 November, 2008
According to the program of Semmelweis Symposium, Peter Pokreisz (Katholieke Universiteit Leuven, Belgium) will give a lecture (in Hungarian) on cGMP regulatory mechanisms in cardiology at 18:00 Wednesday, 26 November.
Abstract submission period extended
14 November 2008
The deadline for abstract submission was extended until 18 November 2008. More detailes on the Abstract submission form.
On-line registration
4 November. 2008
Participation in the program of Semmelweis Symposium 2008 is free. However, completion the on-line registration form is required to attend the Symposium. Abstract submission for poster presentation
3 November, 2008
Abstracts for poster presentation are welcome to the Semmelweis Symposium. Deadline for abstract submission is 15 November. More detailes on the Abstract Submission Form.
PhD course registration
2 November, 2008
Semmelweis Symposium 2008 was accredited by the School of Doctoral Studies of Semmelweis University. Students attending all the three days of the Symposium will get 2 PhD credits.
OFTEX registration
2 November, 2008
Semmelweis Symposium 2008 was registred to the OFTEX system. Colleagues attending all the three days of the Symposium will get 20 OFTEX credits. For detailed information look for SE-TK/2008-07/00383 at www.oftex.hu .
Final program
30 October, 2008
The final program of the Symposium has been completed. For detailes visit to the Scientific Program pages.
Current trends in Cardiology
18 August. 2008
This year cardiology is in the focus of Semmelweis Symposium. The members of the Heart Center take the opportunity to kindly invite you to this event.
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Cardiomyocyte-specific overexpression of type 5 phosphodiesterase impairs functional recovery after myocardial infarction.
- P. Pokreisz (1), A. Van Den Bergh (2), V. Bito (2), G. Marsboom (1), S. Vandenwijngaert (1), X. Liu (2), K. Sipido (2), P.Herijgers (2), KD. Bloch (3), S. Janssens (1)
- (1) Katholieke Universiteit Leuven and VIB, Leuven, Belgium
(2) KU Leuven, Leuven, Belgium
(3) MGH and Harvard Medical School, Boston, United States of America
Purpose: Cyclic guanosine monophosphate (cGMP), a second-messenger regulator of cardiovascular function, modulates acute and chronic stress responses in theheart. Myocardial cGMP levels are determined by the balance between productionvia guanylate cyclases and hydrolysis via phosphodiesterases (PDEs). To better understand the role of cGMPhydrolysis in the myocardial response to hemodynamic challenge, we generatedtransgenic mice with cardiomyocyte-specific overexpression of a cGMP-specificPDE (PDE5TG) and compared the LV remodeling esponse to myocardial infarction(MI) with wild-type littermates (WT). Methods:PDE expression was examined in hearts of WT and PDE5-TG using qRTPCR,immunoblotting, immunohistochemistry confocal microscopy, and activity measurement. Cell shortening and calcium handling were determined in paced adult cardiomyocytes. Murine LV function and dimensions were compared before and10 weeks after LAD ligation at baseline and following beta-adrenergic stimulation using closed-chest pressure-volume catheterization and morphometry. Results:The PDE5 transgene was selectively overexpressed in cardiomyocytes of PDE5-TG and associated with 10-fold higher cGMP-catabolism. Calcium-currents and cell shortening did not differ between genotypes. After MI, cardiac dimensions were larger in PDE5-TG than in WT and for a similar infarct size, LV end-systolic and-diastolic volumes were larger in PDE5-TG than in WT (57±5 vs 39±4 and 65±6 vs 48±4 μL, respectively, P<0.01, for both), and isovolumic relaxation was more prolonged (10±1 vs 8±1 ms, P<0.05). After MI, preloadrecruitablestroke work was significantly lower in PDE5-TG than in WT at baseline and during adrenergic stress. Conclusions: Cardiomyocyte-specific overexpression of PDE5 does not alter baseline cardiac structure or function, but significantly impairs systolic and diastolic function and LV remodeling after MI. Myocardial PDEs are important novel targets in post-infarction heart failure.
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