INFORMATION

Date: 27-29 November 2008

Fax: +36-1-4586842
Email: symposium@kardio.sote.hu
Visit the homepage of the Heart Center.
CONFERENCE NEWS
Symposium lectures on-line
20 February, 2009
Most of the lectures of the Symposium were published on-line. You can find the video presentations at the top of each lecture abstract. We hope to complete the whole on-line program in the near feature.
Pictures of Semmelweis Symposium 2008
1 January, 2009
You can find the pictures of all the three days of Semmelweis Symposium 2008 here.
Lecture of Prof. Sándor Kovács
31 December, 2008
You can find the whole video-presentation of Prof. Sándor Kovács at "Lectures" on the following page.
Summary
30 November, 2008
More than 500 participants from 20 countries attended Semmelweis Symposium 2008. You can find a detailed summary of the event here. A summary of press echo in the Hungarian media you can find here.
Poster abstracts
27 November, 2008
You can find the poster abstracts of Semmelweis Symposium 2008 here.
Scientific Program - printable version
23 November, 2008
You can download the printable version of the Scientific Program here.
Cardiovascular pharmacogenomics course
22 November, 2008
According to the program of Semmelweis Symposium, Peter Pokreisz (Katholieke Universiteit Leuven, Belgium) will give a lecture (in Hungarian) on cGMP regulatory mechanisms in cardiology at 18:00 Wednesday, 26 November.
Abstract submission period extended
14 November 2008
The deadline for abstract submission was extended until 18 November 2008. More detailes on the Abstract submission form.
On-line registration
4 November. 2008
Participation in the program of Semmelweis Symposium 2008 is free.
However, completion the on-line registration form is required to attend the Symposium.
Abstract submission for poster presentation
3 November, 2008
Abstracts for poster presentation are welcome to the Semmelweis Symposium. Deadline for abstract submission  is 15 November. More detailes on the Abstract Submission Form.
PhD course registration
2 November, 2008
Semmelweis Symposium 2008 was accredited by the School of Doctoral Studies of Semmelweis University. Students attending all the three days of the Symposium will get 2 PhD credits.
OFTEX registration
2 November, 2008
Semmelweis Symposium 2008 was registred to the OFTEX system. Colleagues attending all the three days of the Symposium will get 20 OFTEX credits. For detailed information look for SE-TK/2008-07/00383 at www.oftex.hu .
Final program
30 October, 2008
The final program of the Symposium has been completed. For detailes visit to the Scientific Program pages.
Current trends in Cardiology
18 August. 2008
This year cardiology is in the focus of Semmelweis Symposium. The members of the Heart Center take the opportunity to kindly invite you to this event.
Scientific Program | Pictures | Lectures | Posters | Location

Early complement activation is associated with unfavorable outcomes in acute ischemic stroke

  • Gábor Széplaki (1), Róbert Szegedi (1), Kristóf Hirschberg (1), Tímea Gombos (1), Lilian Varga (1), István Karádi (1), László Entz (1), Zoltán Széplaki (1), Peter Garred (2), Zoltán Prohászka (1), George Füst (1)
  • (1)Semmelweis University (Budapest, HU);
    (2)Rigshospitalet (Copenhagen, DK)
According to data from animal models, complement activation plays a major role in the brain injury after acute ischemic stroke. Scarce findings are, however, available on the detection and changes of complement activation products in stroke patients. We have measured plasma levels of the five complement activation products (C1rC1sC1inh, C4d, C3a, C5a and SC5b-9) and serum C-reactive protein (CRP) levels in samples obtained from 26 patients with ischemic stroke upon admission. Twenty-six patients with severe carotid atherosclerosis served as controls. Levels of two activation products (SC5b-9 and C4d) were significantly higher in the plasma of stroke patients, as compared with the control group and the concentration of all but one (C1rC1sC1inh) increased significantly during the acute phase (48 hours post-admission) of stroke. Early SC5b-9 levels (measured at admission) exhibited significant positive correlation with the clinical severity of stroke, with the severity of neurological deficit determined using the National Institutes of Health Stroke Scale, as well as with the level of functional disability rated according to the modified Rankin Scale, and were negatively correlated to the Barthel Index. These findings suggest a major role for complement activation in the development of brain infarct, and indicate the potential usefulness of complement-modulating therapy in ischemic stroke.
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