INFORMATION

Date: 27-29 November 2008

Fax: +36-1-4586842
Email: symposium@kardio.sote.hu
Visit the homepage of the Heart Center.
CONFERENCE NEWS
Symposium lectures on-line
20 February, 2009
Most of the lectures of the Symposium were published on-line. You can find the video presentations at the top of each lecture abstract. We hope to complete the whole on-line program in the near feature.
Pictures of Semmelweis Symposium 2008
1 January, 2009
You can find the pictures of all the three days of Semmelweis Symposium 2008 here.
Lecture of Prof. Sándor Kovács
31 December, 2008
You can find the whole video-presentation of Prof. Sándor Kovács at "Lectures" on the following page.
Summary
30 November, 2008
More than 500 participants from 20 countries attended Semmelweis Symposium 2008. You can find a detailed summary of the event here. A summary of press echo in the Hungarian media you can find here.
Poster abstracts
27 November, 2008
You can find the poster abstracts of Semmelweis Symposium 2008 here.
Scientific Program - printable version
23 November, 2008
You can download the printable version of the Scientific Program here.
Cardiovascular pharmacogenomics course
22 November, 2008
According to the program of Semmelweis Symposium, Peter Pokreisz (Katholieke Universiteit Leuven, Belgium) will give a lecture (in Hungarian) on cGMP regulatory mechanisms in cardiology at 18:00 Wednesday, 26 November.
Abstract submission period extended
14 November 2008
The deadline for abstract submission was extended until 18 November 2008. More detailes on the Abstract submission form.
On-line registration
4 November. 2008
Participation in the program of Semmelweis Symposium 2008 is free.
However, completion the on-line registration form is required to attend the Symposium.
Abstract submission for poster presentation
3 November, 2008
Abstracts for poster presentation are welcome to the Semmelweis Symposium. Deadline for abstract submission  is 15 November. More detailes on the Abstract Submission Form.
PhD course registration
2 November, 2008
Semmelweis Symposium 2008 was accredited by the School of Doctoral Studies of Semmelweis University. Students attending all the three days of the Symposium will get 2 PhD credits.
OFTEX registration
2 November, 2008
Semmelweis Symposium 2008 was registred to the OFTEX system. Colleagues attending all the three days of the Symposium will get 20 OFTEX credits. For detailed information look for SE-TK/2008-07/00383 at www.oftex.hu .
Final program
30 October, 2008
The final program of the Symposium has been completed. For detailes visit to the Scientific Program pages.
Current trends in Cardiology
18 August. 2008
This year cardiology is in the focus of Semmelweis Symposium. The members of the Heart Center take the opportunity to kindly invite you to this event.
Scientific Program | Pictures | Lectures | Posters | Location

Mathematical modeling of cardiovascular function


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Prof. Dr. Sándor Kovács, born in Budapest, left Hungary in 1956, and immigrated to the USA in 1959. He obtained his BS from Cornell University in engineering, his PhD from California Institute of Technology (Caltech) in theoretical physics and his MD from the University of Miami’sPhD to MD program. He trained in internal medicineand cardiology at Washington University in St. Louis andjoined the faculty in 1985. He is Professor of Medicine, Physics, Biomedical Engineering and Physiology and is an invasive cardiologist. His research group includes doctoral students in physiology, biomedical engineering, physics and MD-PhD students. His interests are in characterizing cardiovascular function via mathematical modeling, with in-vivo validation using invasive and noninvasive methods. He has published over 150 manuscripts, abstracts and book chapters and is the current president of the Cardiovascular System Dynamics Society [http://www.csds.org/]. He was awarded the Sjöstrand medal of the Swedish Society of Medicine and Physiology in 2007. TheNIH, American Heart Association, Veteran’s Administration, Whitaker Foundation, Barnes-Jewish Hospital Foundation,Alan A. and Edith L Wolff Charitable trust and Philips Medical Systems have funded his research.

Abstract

To understand how the heart works when it fills requires recognition that all hearts decrease their pressure (dP/dt<0) while they initiate filling (dV/dt>0), hence (dP/dV<0) and they are mechanical suction pumps. Modeling the suction pump feature of filling allows understanding of transmitral Doppler flow contours in physical, physiologic and causal terms. It naturally leads to consideration of the constant volume attribute of the 4-chamberedheart and thereby reveals that the equilibrium volume of the left ventricle is the volumeat diastasis. With these insights solution of the load-independent index of diastolic function problem, and load-independent index of isovolumic pressure decay problem can beachieved. For clinicians, these developments herald the era of diagnosis and management of heart failure patients, 50% of whom have normal ejection fraction, using indexes that are load independent and that reveal attributes of intrinsic diastolic function. For cellular and molecular biologists model based predictions and constraints provide a roadmap thatcan guide the thrust of their investigation to explain the observed and model-predicted macroscopic phenomena.
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