INFORMATION

Date: 27-29 November 2008

Fax: +36-1-4586842
Email: symposium@kardio.sote.hu
Visit the homepage of the Heart Center.
CONFERENCE NEWS
Symposium lectures on-line
20 February, 2009
Most of the lectures of the Symposium were published on-line. You can find the video presentations at the top of each lecture abstract. We hope to complete the whole on-line program in the near feature.
Pictures of Semmelweis Symposium 2008
1 January, 2009
You can find the pictures of all the three days of Semmelweis Symposium 2008 here.
Lecture of Prof. Sándor Kovács
31 December, 2008
You can find the whole video-presentation of Prof. Sándor Kovács at "Lectures" on the following page.
Summary
30 November, 2008
More than 500 participants from 20 countries attended Semmelweis Symposium 2008. You can find a detailed summary of the event here. A summary of press echo in the Hungarian media you can find here.
Poster abstracts
27 November, 2008
You can find the poster abstracts of Semmelweis Symposium 2008 here.
Scientific Program - printable version
23 November, 2008
You can download the printable version of the Scientific Program here.
Cardiovascular pharmacogenomics course
22 November, 2008
According to the program of Semmelweis Symposium, Peter Pokreisz (Katholieke Universiteit Leuven, Belgium) will give a lecture (in Hungarian) on cGMP regulatory mechanisms in cardiology at 18:00 Wednesday, 26 November.
Abstract submission period extended
14 November 2008
The deadline for abstract submission was extended until 18 November 2008. More detailes on the Abstract submission form.
On-line registration
4 November. 2008
Participation in the program of Semmelweis Symposium 2008 is free.
However, completion the on-line registration form is required to attend the Symposium.
Abstract submission for poster presentation
3 November, 2008
Abstracts for poster presentation are welcome to the Semmelweis Symposium. Deadline for abstract submission  is 15 November. More detailes on the Abstract Submission Form.
PhD course registration
2 November, 2008
Semmelweis Symposium 2008 was accredited by the School of Doctoral Studies of Semmelweis University. Students attending all the three days of the Symposium will get 2 PhD credits.
OFTEX registration
2 November, 2008
Semmelweis Symposium 2008 was registred to the OFTEX system. Colleagues attending all the three days of the Symposium will get 20 OFTEX credits. For detailed information look for SE-TK/2008-07/00383 at www.oftex.hu .
Final program
30 October, 2008
The final program of the Symposium has been completed. For detailes visit to the Scientific Program pages.
Current trends in Cardiology
18 August. 2008
This year cardiology is in the focus of Semmelweis Symposium. The members of the Heart Center take the opportunity to kindly invite you to this event.
Scientific Program | Pictures | Lectures | Posters | Location

Molecular regulation of myocardial contractility


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Professor Dr. Miklós Tóth graduated at Semmelweis Medical University, Budapest in 1986 and also from the Medical Faculty of the Ruprecht Karl University in Heidelberg. He spent 3 years in Heidelberg in Detlev Ganten’s laboratory and also three years in Oulu in Heikki Ruskoaho’s research group. Currently he is head and chairman of the Department of Health Sciences and Sport Medicine at Semmelweis University, Budapest. He is the Scientific Secretaryof the Medical Section of the Hungarian Academy of Sciences and also the COO of the Szentágothai János Knowledge Centre. He specialized in internal medicine in 1998. His main research interest is in cardiac endocrine function, heart hypertrophy and inotropic regulation of the ventricular function. He published more then 90 scientific articles. He completed his PhD thesis 1995 and the DSc thesis in 2002. In the University School of PhD studies 8 of his students have defended their PhD theses.

Abstract

Cardiac contractile function is regulated by catecholamines, the force frequency relationship and the Frank-Starling mechanism. Recently a series of endogenous substances have been described as positive inotropic agents. Among others adrenomedullin (AM), apelin (AP), endothelin, angiotensin II, ouabain. AM and AP are not only circulating peptides but are also produced by the heart and their respective receptors are present in the myocardium. In an isolated Langendorf heart model both AM and AP have proved to have strong inotropic effect. The maximal effect is 70 % of the maximal inotropic effect of isoproterenol. However AM and AP exert their maximal effect with concentrations 4 magnitudes lower as compared to isoproterenol. The effect is mediated by other intracellular mechanisms then cyclic-AMP. We suggest that AM and AP are novel mechanisms of cardiac contractile adaptability.
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